dapivirine
Trials 37 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 7 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 15 trials | ||||||
| Phase 1 | NCT05416021 Comparator | Aug 2022 → Apr 2024 | HIV infectious disease | International Partnership for Microbicides, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT03044379 Comparator | Sep 2015 → Sep 2017 | HIV infectious disease | International Partnership for Microbicides, Inc. | Withdrawn | No outcome recorded |
| Phase 1 | NCT02847286 Comparator | Sep 2015 → Nov 2016 | — | International Partnership for Microbicides, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT02858024 Comparator | Jan 2015 → Apr 2016 | HIV infectious disease | International Partnership for Microbicides, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT01277640 Comparator | Mar → Jul 2011 | — | International Partnership for Microbicides, Inc. | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00799058 Comparator | Jul 2009 → Jan 2011 | HIV infectious disease | International Partnership for Microbicides, Inc. | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT07076043 Comparator | Jun 2025 → Dec 2028 expected | HIV infectious disease | University of Alabama at Birmingham | Recruiting | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 49 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | dapivirine | “We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days compared to a dapivirine-only ring (DVR-200mg) in MTN-030/IPM 041 (n...” PMID 39808648 ↗ Jan 202543“containing the active ingredients dapivirine (DPV) and levonorgestrel (LNG), formulated as IPM VR: 200 mg DPV + 320 mg LNG (Ring-102)” NCT03467347 ↗ “To start, the dapivirine vaginal ring will be included among the other forms of PrEP that are available.” NCT07076043 ↗ “They then underwent 7-day exposure to a ring containing 120 mg of TMC120 (dapivirine).” NCT00700284 ↗ “DPV-LNG Ring containing xx mg of dapivirine + xx mg of levonorgestrel” NCT05041699 ↗ |
| Known as | [14C]DAPIVIRINE | ChEMBL registry synonym — accepted as the source's own label CHEMBL70663 ↗ |
| Known as | AIDS-105293 | ChEMBL registry synonym — accepted as the source's own label CHEMBL70663 ↗ |
| Known as | DAPIRING | “DAPIRING (Dapivirine) 25mg Vaginal Ring” NCT06250504 ↗ |
| Known as | Dapivirina | ChEMBL registry synonym — accepted as the source's own label CHEMBL70663 ↗ |
| Known as | dapivirine gel 4759 | “dapivirine gel 4759, 0.05%, 2.5g applied once daily” NCT00799058 ↗ |
| Known as | Dapivirine Gel 4789 | “A Double-blind, Randomized, Placebo-Controlled Phase I/II Study to Evaluate the Safety and Acceptability of Dapivirine Gel 4789, 0.05%, 2.5g, a Vaginal Microbicide, Conducted...” NCT00917904 ↗1“dapivirine gel 4789, 0.05%, 2.5g applied once daily” NCT00799058 ↗ |
| Known as | DPV | “We evaluated the safety, pharmacokinetics, and acceptability of a microbicide dapivirine (DPV) vaginal ring (VR) versus placebo in postmenopausal women.” PMID 30289485 ↗ Mar 20196“This study will evaluate the safety and drug detection of the dapivirine (DPV) vaginal ring (VR) and oral Truvada in breastfeeding mother-infant pairs.” NCT04140266 ↗ “Prior trials of a 25 mg dapivirine (DPV) ring have shown a favourable safety profile and approximately 30% risk reduction of HIV-1 infection.” PMID 34118115 ↗ Jun 2021 “containing the active ingredients dapivirine (DPV) and levonorgestrel (LNG), formulated as IPM VR: 200 mg DPV + 320 mg LNG (Ring-102)” NCT03467347 ↗ “Dapivirine (DPV), formulated as vaginal ring, demonstrated HIV risk reduction.” PMID 34498980 ↗ Dec 2021 “Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor” PMID 24070431 ↗ Oct 2013 “Dapivirine (DPV) Vaginal Ring (VR)” NCT03965923 ↗ |
| Known as | Gel-02 | ChEMBL registry synonym — accepted as the source's own label CHEMBL70663 ↗ |
| Known as | R-147681 | ChEMBL registry synonym — accepted as the source's own label CHEMBL70663 ↗ |
| Known as | TMC120 | “candidate microbicide dapivirine (TMC120) for 7 days” NCT00332995 ↗5“pharmacokinetics of dapivirine (TMC120) gel” NCT00304642 ↗ “dapivirine (TMC120) vaginal gel” NCT00309205 ↗ “dapivirine (TMC120) vaginal gel” NCT00304668 ↗ “dapivirine (TMC120) vaginal gel” NCT00303576 ↗ |
| Action | Inhibit | “Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor” PMID 24070431 ↗ Oct 2013 |
| Modality | Small molecule | “Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor” PMID 24070431 ↗ Oct 2013 |
| Route | Other | “intravaginal gel, dosed daily” NCT00613249 ↗ |