Drugs / Diethylcarbamazine
Diethylcarbamazine
also known as
DEC · Banocide · Camin · Decacide · DIETHYLCARBAMAZINE CITRATE · Dietilcarbamazina · Difil · Dirocide · +4 more
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | HETRAZAN | — | 1950-11-13 | fda.gov ↗ |
Trials 7 · a red edge is where a trial was stopped
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 24 trials | ||||||
| Phase 2 | NCT06070116 | Apr 2024 → Sep 2026 expected | ocular onchocerciasis | Washington University School of Medicine | Active not recruiting | No outcome recorded |
| Phase 2 | NCT04188301 | Dec 2019 → Mar 2022 | onchocerciasis | Washington University School of Medicine | Completed | No outcome recorded |
| Phase 2 | NCT03664063 | Sep → Oct 2018 | filariasis, yaws | Lihir Medical Centre | Completed | No outcome recorded |
| Phase 2 | NCT01975441 | May 2014 → Dec 2017 | filariasis | University Hospitals Cleveland Medical Center | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT02005653 | Feb 2009 → Sep 2011 | filariasis | Indian Council of Medical Research | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT02974049 | Jan 2015 → Sep 2018 | filariasis | University Hospitals Cleveland Medical Center | Completed | No outcome recorded |
| — | NCT00295698 | Aug 2001 → Nov 2002 | HIV infectious disease, filariasis | DBL -Institute for Health Research and Development | Completed | No outcome recorded |
Also used as a comparator or background therapy in 9 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT02845713 Comparator | Apr → Jun 2016 | filariasis | University Hospitals Cleveland Medical Center | Completed | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT01111305 Comparator | Apr 2010 → Jan 2016 | loiasis | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase 2 | NCT00511004 Comparator | Jul 2007 → Feb 2014 | filariasis | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase 2 | NCT00375583 Background | Sep 2006 → Apr 2011 | filariasis | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT04410406 Comparator | Aug 2020 → Oct 2024 | filariasis | Washington University School of Medicine | Completed | No outcome recorded |
| Phase 3 | NCT03676140 Background | Oct → Dec 2018 | filariasis, scabies, strongyloidiasis, trachoma +1 | Lihir Medical Centre | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT01593722 Comparator | Apr 2012 → Aug 2013 | loiasis | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT03177993 Background | Jul → Nov 2017 | Nematoda infectious disease, filariasis, impetigo, scabies | Washington University School of Medicine | Completed | No outcome recorded |
| — | NCT02899936 Comparator | Jul 2016 → Apr 2017 | filariasis | Washington University School of Medicine | Completed | No outcome recorded |
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 18 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | diethylcarbamazine | “Albendazole and diethylcarbamazine (DEC) are currently used in combination for annual mass treatment of lymphatic filariasis in all parts of the world except Africa.” NCT00375583 ↗15“Lymphatic Filariasis Mass Drug Administration (MDA) with triple drug therapy of ivermectin, diethylcarbamazine, and albendazole (IDA).” NCT03177993 ↗ “diethylcarbamazine (DEC) and albendazole (ALB) are administered in areas where onchocerciasis is not co-endemic.” NCT02899936 ↗ “diethylcarbamazine (DEC. 6 mg/kg)” PMID 37205721 ↗ May 2023 |
| Known as | Banocide | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | Camin | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | DEC | “The present study examines the three-way interaction between HIV infection, lymphatic filariasis caused by the helminth parasite W. bancrofti and the drug diethylcarbamazine (DEC).” NCT00295698 ↗6“Participants will be given a dose of oral Ivermectin (IVM) (150 µg/kg), Diethylcarbamazine (DEC) (6 mg/kg) and Albendazole (ALB) (400 mg)” NCT06070116 ↗ “diethylcarbamazine (DEC) and albendazole (ALB) are administered in areas where onchocerciasis is not co-endemic.” NCT02899936 ↗ “Diethylcarbamazine (DEC) is a drug of choice to treat lymphatic filariasis (LF)” PMID 34310218 ↗ Jul 2021 “Diethylcarbamazine citrate (DEC) treatment of Loa loa infection” NCT01111305 ↗ “Diethylcarbamazine (DEC) 6mg/kg” NCT04410406 ↗ |
| Known as | Decacide | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | DIETHYLCARBAMAZINE CITRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | Dietilcarbamazina | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | Difil | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | Dirocide | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | Ethylaminoazine citrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | Hetrazan | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | Loxuran | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Known as | NSC-80513 | ChEMBL registry synonym — accepted as the source's own label CHEMBL684 ↗ |
| Modality | Small molecule | — CHEMBL684 ↗ |
| Route | Oral | “DEC (taken by mouth)” NCT01111305 ↗ |