Trials 10
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial · 1 missed | ||||||
| Phase 1 | NCT04238416 | Nov 2019 → Dec 2021 | hepatic encephalopathy, liver disorder | Post Graduate Institute of Medical Education and Research, Chandigarh | Completed | Missed primary |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT01362595 | Jun 2013 → Jun 2018 | Diamond-Blackfan anemia, congenital anemia | Northwell Health | Completed | No outcome recorded |
| Phase 25 trials · 1 met primary · 3 missed | ||||||
| Phase 2 | NCT07670195 | Jul 2026 → Jun 2027 expected | traumatic brain injury, traumatic encephalopathy | Akiva Cohen | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06829498 | Apr 2025 → Aug 2026 overdue | brain injury, traumatic encephalopathy | Akiva Cohen | Active not recruiting | Missed primary |
| Phase 2 | NCT03364335 | Jan → Aug 2018 | obesity disorder | NuSirt Biopharma | Completed | Met primary |
| Phase 2 | NCT02546609 | Nov 2015 → Nov 2016 | NAFLD1 | NuSirt Biopharma | Completed | Missed primary |
| Phase 2 | NCT02151461 | Jul 2014 → Aug 2015 | type 2 diabetes mellitus | NuSirt Biopharma | Completed | Missed primary |
| Phase 31 trial | ||||||
| Phase 3 | NCT06121479 | Nov 2023 → Sep 2025 overdue | — | Mahidol University | Enrolling by invitation | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT03644836 | Jan 2015 → Jan 2018 | chronic obstructive pulmonary disease | Poitiers University Hospital | Completed | No outcome recorded |
| — | NCT00005889 | Oct 1999 → ? | hyperglycemia | National Center for Research Resources (NCRR) | Unknown | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| — | NCT00152945 Background | Apr 2005 → Jul 2008 | — | University Health Network, Toronto | Completed | No outcome recorded |
Evidence & citations 4 cited values
Every value below carries the sentence it was read from. 11 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | leucine | “In preclinical, analysis of ipsilateral hippocampi isolated from mice after traumatic brain injury (TBI) demonstrated that only the concentrations of the three branched chain...” NCT06829498 ↗10“In preclinical, analysis of ipsilateral hippocampi isolated from mice after traumatic brain injury (TBI) demonstrated that only the concentrations of the three branched chain...” NCT07670195 ↗ “The use of branched-chain amino acids (AARs) such as valine, leucine, isoleucine in this indication can be fully justified because they stimulate protein synthesis and promote...” NCT03644836 ↗ “Each sachet contains 6.84 grams of BCAA (valine 1.82 grams, leucine 3.29 grams, isoleucine 1.72 grams), total protein 17.08 grams, carbohydrates 25.48 grams, fat 5.66 grams,...” NCT06121479 ↗ “The objective of this study was to evaluate the effects of a triple combination of leucine, metformin, and sildenafil (NS-0200) on body weight and obesity comorbidities in a...” PMID 30569637 ↗ Jan 2019 “two fixed-dose combinations of leucine and sildenafil or two fixed-dose combinations of leucine, sildenafil and metformin” NCT03364335 ↗ “Branched-Chain Amino Acids (BCAA; Isoleucine, leucine and valine) have attracted particular interest” PMID 30568347 ↗ Jun 2018 “1100 mg L Leucine in combination with 125 mg of Metformin BID” NCT02151461 ↗ |
| Known as | deuterated leucine | “The form of leucine that will be administered is deuterated leucine” NCT00152945 ↗ |
| Modality | Small molecule | “Leucine, an amino acid and glycerol, an intermediary metabolite” NCT00152945 ↗ |
| Route | Intravenous | “[1-C]leucine IV over 10 hours” NCT00005889 ↗ |