drugset / Trial / NCT03644836

Interest of Branched Chain Amino Acids Associated With a Respiratory Rehabilitation Program in Patients Broncho Chronic Obstructive Pulmonary Disease

NCT03644836

Completed 60 enrolled Poitiers University Hospital
RandomizedParallel-groupDouble-blindTreatment

Summary

Respiratory rehabilitation is one of the main treatments for COPD in the early stages of the disease (Stage 2 of GOLD) with a recognized effect on improving the capacity of the patients to exert effort by fighting against deconditioning. the effort. This treatment also improves the quality of life of patients and reduces the risk of respiratory exacerbations. The patients are very often malnourished and various studies have proposed the addition of oral supplementation such as hormone therapy (testosterone) to improve the exercise performance of these atrophied muscles. The use of branched-chain amino acids (AARs) such as valine, leucine, isoleucine in this indication can be fully justified because they stimulate protein synthesis and promote muscle maintenance and repair.

Timeline

Start
2015-01-21
Primary completion
2018-01-31
Completion
2018-03-05

Drugs

EvaluationDrugModalityDoseRoute
Subject amino acids Unknown
Subject isoleucine Other / unclassified
Subject valine Other / unclassified