Drugs / Enlicitide Decanoate
last change Jul 2026 re-read 2 minutes ago

Enlicitide Decanoate

also known as MK-0616

targets PCSK9 via inhibition

Developed for
familial hypercholesterolemia · hyperlipidemia · arteriosclerosis disorder
Investigated by
Merck Sharp & Dohme LLC · Celerion

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) LIPFENDRA 2026-07-15 fda.gov

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT06625814 Jul → Aug 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06772792 Apr → Jun 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06772779 Apr → Jun 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06691906 Mar → May 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06699329 Jan → May 2024 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06699355 Nov → Dec 2023 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06658652 Oct → Dec 2023 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT05934292 Jul 2023 → Jan 2024 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT06592339 Oct → Dec 2022 hyperlipoproteinemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07058077 Aug 2025 → Dec 2033 expected familial hypercholesterolemia Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 33 trials
Phase 3 NCT06492291 Aug 2024 → Oct 2028 expected Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 3 NCT06008756 Oct 2023 → Nov 2029 expected arteriosclerosis disorder, hyperlipidemia Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 3 NCT05952856 Aug 2023 → Jul 2025 familial hypercholesterolemia Merck Sharp & Dohme LLC Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 14 sources stand behind the page.

FieldValueCited text
Known as Enlicitide Decanoate ClinicalTrials.gov intervention name — accepted as the source's own label NCT07058077
11

NCT06699329

NCT06691906

NCT05952856

NCT05934292

NCT06625814

NCT06658652

NCT06772779

NCT06699355

NCT06772792

NCT06492291

NCT06008756

Known as MK-0616 “Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor)” NCT05934292
3

“Enlicitide decanoate (MK-0616, the study medicine)” NCT06658652

MK-0616NCT06008756

NCT06592339

Action Inhibit “PCSK9 Inhibitor” NCT05934292
Route Oral “single dose orally” NCT05934292
Target PCSK9 “oral PCSK9 inhibitor enlicitide” PMID 41879224 Feb 2026