Drugs / tirapazamine
tirapazamine
Trials 20
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 14 trials | ||||||
| Phase 1 | NCT00098995 | Dec 2004 → Jan 2010 | cervical cancer | Peter MacCallum Cancer Centre, Australia | Completed | No outcome recorded |
| Phase 1 | NCT00033410 | Mar 2002 → ? | lung cancer | California Cancer Consortium | Completed | No outcome recorded |
| Phase 1 | NCT00005078 | Mar 2000 → Jul 2012 | cancer of unknown primary site | City of Hope Medical Center | Completed | No outcome recorded |
| Phase 1 | NCT00003288 | Aug 1998 → Jun 2003 | childhood malignant neoplasm | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT06848556 | May 2021 → Nov 2023 | hepatocellular carcinoma | Zhejiang Raygene Pharmaceuticals Co., Ltd | Terminated | No outcome recorded Stop: Business |
| Phase 1/2 | NCT02174549 | Sep 2014 → Mar 2028 expected | hepatocellular carcinoma, neuroendocrine neoplasm | Teclison Ltd. | Recruiting | No outcome recorded |
| Phase 28 trials · 1 missed | ||||||
| Phase 2 | NCT04701476 | May 2021 → Mar 2027 expected | colorectal cancer | Teclison Ltd. | Recruiting | No outcome recorded |
| Phase 2 | NCT03145558 | Dec 2017 → Jun 2024 | hepatocellular carcinoma | Teclison Ltd. | Terminated | No outcome recorded |
| Phase 2 | NCT03259867 | Jul 2017 → Dec 2026 expected | gastric cancer, hepatocellular carcinoma | Teclison Ltd. | Recruiting | No outcome recorded |
| Phase 2 | NCT00066742 | Sep 2003 → Aug 2009 | small cell lung carcinoma | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 2 | NCT00025363 | Nov 2001 → Oct 2007 | alveolar rhabdomyosarcoma, childhood botryoid rhabdomyosarcoma | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 2 | NCT00020696 | Jun 2001 → Apr 2006 | ovarian carcinoma, peritoneal carcinoma | Gynecologic Oncology Group | Completed | No outcome recorded |
| Phase 2 | NCT00003369 | Aug 1998 → Oct 2003 | cervical cancer | SWOG Cancer Research Network | Completed | No outcome recorded |
| Phase 2 | NCT00002774 | Jun 1996 → Jun 2000 | head and neck squamous cell carcinoma | Stanford University | Completed | Missed primary |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT06844357 | Mar 2025 → Apr 2029 expected | hepatocellular carcinoma | Zhejiang Raygene Pharmaceuticals Co., Ltd | Recruiting | No outcome recorded |
| Phase 35 trials · 2 missed | ||||||
| Phase 3 | NCT00262821 | Feb 2006 → Aug 2010 | cervical adenosquamous carcinoma | National Cancer Institute (NCI) | Terminated | Missed primary |
| Phase 3 | NCT00174837 | Apr 2005 → Jan 2008 | head and neck squamous cell carcinoma | Sanofi | Completed | No outcome recorded |
| Phase 3 | NCT00094081 | Oct 2002 → Sep 2006 | head and neck neoplasm | Sanofi | Completed | No outcome recorded |
| Phase 3 | NCT00006484 | Nov 2000 → Apr 2006 | lung cancer | SWOG Cancer Research Network | Completed | Missed primary |
| Phase 3 | NCT00017459 | Jul 2000 → Feb 2004 | lung cancer | Sanofi | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 1 | NCT00006487 Comparator | Oct 2000 → Jul 2004 | lung cancer | SWOG Cancer Research Network | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 22 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | tirapazamine | “TATE: Trans-arterial Tirapazamine Embolization;” NCT04701476 ↗ |
| Known as | NSC 130181 | “Phase I Dose Escalation Study of Tirapazamine (NSC 130181) in Combination With Carboplatin and Paclitaxel in Advanced Malignant Solid Tumors” NCT00005078 ↗ |
| Known as | SML-0552 | ChEMBL registry synonym — accepted as the source's own label CHEMBL50882 ↗ |
| Known as | SR-4233 | ChEMBL registry synonym — accepted as the source's own label CHEMBL50882 ↗ |
| Known as | SR259075 | “tirapazamine (SR259075)” NCT00094081 ↗ |
| Known as | Tirapazamina | ChEMBL registry synonym — accepted as the source's own label CHEMBL50882 ↗ |
| Known as | Tirazone | ChEMBL registry synonym — accepted as the source's own label CHEMBL50882 ↗ |
| Known as | WIN 59075 | ChEMBL registry synonym — accepted as the source's own label CHEMBL50882 ↗ |
| Modality | Small molecule | “Tirapazamine is a benzotriazine with selective cytotoxicity for hypoxic cells.” NCT00002774 ↗ |
| Route | Other | “tirapazamine infusion” NCT00002774 ↗ |