Drugs / tirapazamine

Trials 20 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT00098995 Dec 2004 → Jan 2010 cervical cancer Peter MacCallum Cancer Centre, Australia Completed No outcome recorded
Phase 1 NCT00033410 Mar 2002 → ? lung cancer California Cancer Consortium Completed No outcome recorded
Phase 1 NCT00005078 Mar 2000 → Jul 2012 cancer of unknown primary site City of Hope Medical Center Completed No outcome recorded
Phase 1 NCT00003288 Aug 1998 → Jun 2003 childhood malignant neoplasm National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06848556 May 2021 → Nov 2023 hepatocellular carcinoma Zhejiang Raygene Pharmaceuticals Co., Ltd Terminated No outcome recorded
Phase 1/2 NCT02174549 Sep 2014 → Mar 2028 expected hepatocellular carcinoma, neuroendocrine neoplasm Teclison Ltd. Recruiting No outcome recorded
Phase 28 trials
Phase 2 NCT04701476 May 2021 → Mar 2027 expected colorectal cancer Teclison Ltd. Recruiting No outcome recorded
Phase 2 NCT03145558 Dec 2017 → Jun 2024 hepatocellular carcinoma Teclison Ltd. Terminated No outcome recorded
Phase 2 NCT03259867 Jul 2017 → Dec 2026 expected gastric cancer, hepatocellular carcinoma Teclison Ltd. Recruiting No outcome recorded
Phase 2 NCT00066742 Sep 2003 → Aug 2009 small cell lung carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00025363 Nov 2001 → Oct 2007 alveolar rhabdomyosarcoma, childhood botryoid rhabdomyosarcoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00020696 Jun 2001 → Apr 2006 ovarian carcinoma, peritoneal carcinoma Gynecologic Oncology Group Completed No outcome recorded
Phase 2 NCT00003369 Aug 1998 → Oct 2003 cervical cancer SWOG Cancer Research Network Completed No outcome recorded
Phase 2 NCT00002774 Jun 1996 → Jun 2000 head and neck squamous cell carcinoma Stanford University Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT06844357 Mar 2025 → Apr 2029 expected hepatocellular carcinoma Zhejiang Raygene Pharmaceuticals Co., Ltd Recruiting No outcome recorded
Phase 35 trials
Phase 3 NCT00262821 Feb 2006 → Aug 2010 cervical adenosquamous carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 3 NCT00174837 Apr 2005 → Jan 2008 head and neck squamous cell carcinoma Sanofi Completed No outcome recorded
Phase 3 NCT00094081 Oct 2002 → Sep 2006 head and neck neoplasm Sanofi Completed No outcome recorded
Phase 3 NCT00006484 Nov 2000 → Apr 2006 lung cancer SWOG Cancer Research Network Completed No outcome recorded
Phase 3 NCT00017459 Jul 2000 → Feb 2004 lung cancer Sanofi Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT00006487 Comparator Oct 2000 → Jul 2004 lung cancer SWOG Cancer Research Network Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 22 sources stand behind the page.

FieldValueCited text
Known as tirapazamine “TATE: Trans-arterial Tirapazamine Embolization;” NCT04701476
20

NCT00262821

NCT00017459

NCT00003288

NCT00020696

NCT06844357

NCT00005078

NCT00003369

NCT00174837

NCT03145558

NCT00025363

NCT00098995

NCT03259867

NCT00033410

NCT00066742

NCT00006484

NCT02174549

NCT00002774

NCT00006487

NCT00094081

NCT06848556

Known as NSC 130181 “Phase I Dose Escalation Study of Tirapazamine (NSC 130181) in Combination With Carboplatin and Paclitaxel in Advanced Malignant Solid Tumors” NCT00005078
Known as SML-0552 ChEMBL registry synonym — accepted as the source's own label CHEMBL50882
Known as SR-4233 ChEMBL registry synonym — accepted as the source's own label CHEMBL50882
Known as SR259075 “tirapazamine (SR259075)” NCT00094081
Known as Tirapazamina ChEMBL registry synonym — accepted as the source's own label CHEMBL50882
Known as Tirazone ChEMBL registry synonym — accepted as the source's own label CHEMBL50882
Known as WIN 59075 ChEMBL registry synonym — accepted as the source's own label CHEMBL50882
Modality Small molecule “Tirapazamine is a benzotriazine with selective cytotoxicity for hypoxic cells.” NCT00002774
Route Other “tirapazamine infusion” NCT00002774