drugset / Trial / NCT00000251
Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3
Phase 2
Completed
10 enrolled
University of Chicago
National Institute on Drug Abuse (NIDA) · collab
RandomizedCrossoverSingle-blindTreatment
Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
Timeline
- Start
- 1994-04
- Primary completion
- 1996-01
- Completion
- 1996-01
Publications
- Background Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL. The acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and psychomotor performance in healthy volunteers. Anesth Analg. 1996 Jan;82(1):153-7. doi: 10.1097/00000539-199601000-00028.
- Whelan J, Hackshaw A, McTiernan A, Grimer R, Spooner D, Bate J, Ranft A, Paulussen M, Juergens H, Craft A, Lewis I. Survival is influenced by approaches to local treatment of Ewing sarcoma within an international randomised controlled trial: analysis of EICESS-92. Clin Sarcoma Res. 2018 Mar 30;8:6. doi: 10.1186/s13569-018-0093-y. eCollection 2018.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Isoflurane | Other / unclassified | 0.2 % | Other |
| Comparator | Isoflurane | Other / unclassified | 0.4 % | Other |
| Comparator | Nitrous Oxide | Other / unclassified | 30 % | Other |