drugset / Trial / NCT00000259
Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11
Non-randomizedCrossoverDouble-blind
Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.
Timeline
- Start
- 1996-08
- Primary completion
- 1997-11
- Completion
- 1997-11
Publications
- Background Anesthesiology. 1997 (in press).
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Nitrous Oxide | Other / unclassified | 15 % | Inhaled |
| Comparator | Nitrous Oxide | Other / unclassified | 30 % | Inhaled |
| Comparator | Sevoflurane | Other / unclassified | 0.3 % | Inhaled |
| Comparator | Sevoflurane | Other / unclassified | 0.6 % | Inhaled |