drugset / Trial / NCT00000924
A Study to Compare Two Different Anti-HIV Drug Regimens
Phase 2
Completed
120 enrolled
National Institute of Allergy and Infectious Diseases (NIAID)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · collab
Treatment
Summary
This study compares 2 different anti-HIV drug regimens to determine which is the most effective in lowering the amount of HIV in the blood. The anti-HIV drugs used in this study are 2 protease inhibitors (nelfinavir and ritonavir), 2 nucleoside reverse transcriptase inhibitors (stavudine and didanosine), and 1 nonnucleoside reverse transcriptase inhibitor (nevirapine). These drug combinations have been previously studied in adults, but there is limited information on how well they work in HIV-infected children. It is important to develop drug combinations which are effective at suppressing the HIV virus in children.
Timeline
- Start
- —
- Primary completion
- —
- Completion
- 2001-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Didanosine | Small molecule | 240 mg/m2 | — |
| Subject | Nelfinavir | Other / unclassified | 30 mg/kg | — |
| Subject | Nelfinavir | Other / unclassified | 50 mg/kg | — |
| Subject | Nelfinavir | Other / unclassified | 55 mg/kg | — |
| Subject | Nevirapine | Small molecule | 120 mg/m2 | — |
| Subject | Ritonavir | Other / unclassified | 400 mg/m2 | — |
| Subject | Stavudine | Other / unclassified | 1 mg/kg | — |