Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Acute Myeloid Leukemia in Second Remission

Phase 2 Completed 51 enrolled Alliance for Clinical Trials in Oncology National Cancer Institute (NCI) · collab

NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of peripheral stem cell transplantation following chemotherapy in treating patients with acute myeloid leukemia in second remission.

Timeline

Start: 1996-06
Primary completion: 2003-02
Completion: 2009-03

Publications

Results Linker CA, Owzar K, Powell B, Hurd D, Damon LE, Archer LE, Larson RA; Cancer and Leukemia Group B. Auto-SCT for AML in second remission: CALGB study 9620. Bone Marrow Transplant. 2009 Sep;44(6):353-9. doi: 10.1038/bmt.2009.36. Epub 2009 Mar 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Busulfan	Small molecule	1 mg/kg	Oral
Background	Cytarabine	Small molecule	2000 mg/m2	Intravenous
Background	Etoposide	Small molecule	60 mg/kg	Intravenous
Background	Methotrexate	Small molecule	12 mg	Intrathecal
Background	filgrastim	Protein / enzyme biologic	10 ug/kg	Subcutaneous

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Acute Myeloid Leukemia in Second Remission

Summary

Timeline

Publications

Drugs

Indications