Biological Therapy in Treating Patients With Glioblastoma Multiforme

Phase 2 Completed 40 enrolled The Cleveland Clinic National Cancer Institute (NCI) · collab

Treatment

Summary

RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. PURPOSE: Phase II trial to study the effectiveness of biological therapy in treating patients with glioblastoma multiforme.

Timeline

Start: 1997-08
Primary completion: —
Completion: 1998-07

Publications

Results Plautz GE, Barnett GH, Miller DW, Cohen BH, Prayson RA, Krauss JC, Luciano M, Kangisser DB, Shu S. Systemic T cell adoptive immunotherapy of malignant gliomas. J Neurosurg. 1998 Jul;89(1):42-51. doi: 10.3171/jns.1998.89.1.0042.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	autologous tumor cell vaccine	Vaccine	—	Intrathecal
Subject	tumor-draining lymph node lymphocyte therapy	Cell therapy	9e+08 cells	Intravenous
Subject	tumor-draining lymph node lymphocyte therapy	Cell therapy	1.5e+11 cells	Intravenous
Background	Cyclophosphamide	Other / unclassified	—	Oral
Background	sargramostim	Protein / enzyme biologic	—	Intrathecal

Biological Therapy in Treating Patients With Glioblastoma Multiforme

Summary

Timeline

Publications

Drugs

Indications