drugset / Trial / NCT00003657
High-dose ICE With Amifostine
NaSingle-groupOpen-labelTreatment
Summary
The purpose of the study is to evaluate the combination of amifostine and high dose chemotherapy with blood stem cell support. Amifostine is a druf developed to protect normal tissues against the toxicities of chemotherapy and radiotherapy and has reduced the side effects of chemotherapy given at conventional doses.
Timeline
- Start
- 1998-07
- Primary completion
- 2000-11
- Completion
- 2002-06
Publications
- Results Elias AD, Richardson P, Tretyakov O, et al.: Amifostine with high dose infosfamide, carboplatin, and etoposide (ICE) with hematopoietic STEM cell support. [Abstract] Proceedings of the American Society of Clinical Oncology 19: A197, 2000.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carboplatin | Small molecule | — | Intravenous |
| Subject | Etoposide | Small molecule | — | Intravenous |
| Subject | Ifosfamide | Small molecule | — | Intravenous |
| Subject | amifostine | Unknown | — | Intravenous |
| Background | filgrastim | Protein / enzyme biologic | — | Subcutaneous |