drugset / Trial / NCT00004442
Study of Bile Acids in Patients With Peroxisomal Disorders
Terminated
25 enrolled
University of Cincinnati
Children's Hospital Medical Center, Cincinnati · collab
Treatment
Summary
OBJECTIVES: I. Determine the effectiveness of oral bile acid therapy with cholic acid, chenodeoxycholic acid, and ursodeoxycholic acid in patients with peroxisomal disorders involving impaired primary bile acid synthesis. II. Determine whether suppression of synthesis of atypical bile acids and enrichment of bile acid pool with this regimen is effective in treating this patient population and improving quality of life.
Timeline
- Start
- —
- Primary completion
- —
- Completion
- 1999-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Chenodeoxycholic Acid | Small molecule | — | Oral |
| Subject | Cholic Acid | Small molecule | — | Oral |
| Subject | Ursodeoxycholic Acid | Small molecule | — | Oral |