drugset / Trial / NCT00004444
Pilot Randomized Study of Paromomycin (Aminosidine) vs Streptomycin for Uncomplicated Pulmonary Tuberculosis
Completed
24 enrolled
FDA Office of Orphan Products Development
University of Illinois at Chicago · collab
RandomizedTreatment
Summary
OBJECTIVES: I. Compare the pharmacokinetics and early bactericidal activity of paromomycin (aminosidine) vs streptomycin for the treatment of uncomplicated pulmonary tuberculosis. II. Compare the tolerability of these two drugs in these patients. III. Establish the relationships between achieved serum concentration, minimal inhibitory concentration, and early bactericidal activity of paromomycin and streptomycin.
Timeline
- Start
- 1994-11
- Primary completion
- —
- Completion
- 2001-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Paromomycin | Small molecule | — | Intramuscular |
| Subject | streptomycin | Other / unclassified | — | Intramuscular |