drugset / Trial / NCT00046852
Chemotherapy and Peripheral Stem Cell Transplantation Followed By Immunotherapy in Treating Patients With Multiple Myeloma
Phase 1/2
Completed
University of Maryland, Baltimore
University of Maryland Greenebaum Cancer Center · collab
RandomizedTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with autologous peripheral stem cell transplantation and immunotherapy may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. PURPOSE: Randomized phase I/II trial to study the effectiveness of combining chemotherapy with peripheral stem cell transplantation followed by immunotherapy in treating patients who have multiple myeloma.
Timeline
- Start
- 2001-12
- Primary completion
- 2004-11
- Completion
- 2008-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclophosphamide | Other / unclassified | — | Intravenous |
| Subject | Melphalan | Small molecule | — | Intravenous |
| Subject | carmustine | Small molecule | — | Intravenous |
| Subject | pneumococcal polyvalent vaccine | Vaccine | — | Intramuscular |
| Subject | therapeutic autologous lymphocytes | Cell therapy | — | Intravenous |
| Background | filgrastim | Protein / enzyme biologic | — | Subcutaneous |
| Background | therapeutic tumor infiltrating lymphocytes | Cell therapy | — | — |