The Renin-Angiotensin System in Essential Hypertension

Summary

Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.

Timeline

Start

2004-04

Primary completion

—

Completion

2006-10

Outcome

Outcome not reported

Stopped (Enrollment): “Insufficient accrual rate”

Drugs

Indications