drugset / Trial / NCT00147836
Evaluation of the Effects of Different Interventions on Glycemic Control in Newly-Diagnosed Type 2 Diabetic Patients
Completed
436 enrolled
Sun Yat-sen University
Guangdong Science and Technology Bureau, China · collabHoffmann-La Roche · collabMinistry of Education, China · collabNovo Nordisk A/S · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to investigate and evaluate the effects of different interventions (1.continuous subcutaneous insulin infusion,2.multiple daily injections, 3.anti-hyperglycemic agents) on glycemic control, B-cell function and the remission rate in newly-diagnosed type 2 diabetic patients.
Timeline
- Start
- 2004-09
- Primary completion
- 2007-10
- Completion
- 2007-10
Publications
- Background Li Y, Xu W, Liao Z, Yao B, Chen X, Huang Z, Hu G, Weng J. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care. 2004 Nov;27(11):2597-602. doi: 10.2337/diacare.27.11.2597.
- Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, Hu Y, Zhou Z, Yan X, Tian H, Ran X, Luo Z, Xian J, Yan L, Li F, Zeng L, Chen Y, Yang L, Yan S, Liu J, Li M, Fu Z, Cheng H. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet. 2008 May 24;371(9626):1753-60. doi: 10.1016/S0140-6736(08)60762-X.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Gliclazide | Small molecule | 160 mg | Oral |
| Comparator | Human Insulin NPH | Protein / enzyme biologic | — | — |
| Comparator | Insulin | Protein / enzyme biologic | — | Subcutaneous |
| Comparator | Metformin | Small molecule | 2 g | — |