Standardized Time- and Score-oriented Treatment of Moderate and Severe Atopic Dermatitis
Summary
The study was designed to test the hypothesis whether a standardized, time-and score-oriented treatment following a strict evidence based algorithm is equally effective to a standard treatment regimen for moderate to severe atopic dermatitis. Study Type: Mono-centre study, patients are blinded, physicians are randomized to either treat study- or controll group Eligible are patients age 2 years or older with SCORAD \>= 20 Duration: 12 Months, study visits every 4 weeks. Primary endpoint is Difference between Baseline SCORAD and mean SCORAD under treatment. Secundary endpoints are quality of life, safety and economic burden in both treatment groups.
Timeline
- Start
- 2004-05
- Primary completion
- 2006-09
- Completion
- 2008-03
Outcome
Missed primary endpoint
paper No statistically significant differences in clinical or subjective response were observed between groups. PMID 18703875 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclosporine | Peptide | — | — |
| Subject | Pimecrolimus | Small molecule | — | — |
| Subject | Prednicarbate | Small molecule | — | — |
| Subject | Prednisolone | Other / unclassified | — | — |
| Subject | Tacrolimus | Small molecule | — | — |