Treatment of Refractory Status Epilepticus

Phase 3 Terminated 23 enrolled Brigham and Women's Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine whether propofol or barbiturates should be preferred in the treatment of status epilepticus (continuous seizure activity) refractory to 2 standard antiepileptic agents.

Timeline

Start: 2006-05
Primary completion: 2010-03
Completion: 2010-03

Publications

Results Rossetti AO, Milligan TA, Vulliemoz S, Michaelides C, Bertschi M, Lee JW. A randomized trial for the treatment of refractory status epilepticus. Neurocrit Care. 2011 Feb;14(1):4-10. doi: 10.1007/s12028-010-9445-z.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Pentobarbital	Small molecule	2 mg/kg	Other
Comparator	Propofol	Small molecule	2 mg/kg	Other
Comparator	Thiopental	Small molecule	2 mg/kg	Other

Indications

No indication recorded.