drugset / Trial / NCT00302211
The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension
RandomizedFactorialDouble-blindTreatment
Summary
The purpose of this multi-center international trial is to evaluate the safety and effectiveness of adding iloprost or placebo (an inactive substance that contains no active study drug) to sildenafil therapy for pulmonary arterial hypertension (PAH). The study will also examine whether patients on sildenafil can reduce the number of iloprost inhalations from the approved 6 doses per day to 4 doses per day.
Timeline
- Start
- 2006-02-01
- Primary completion
- 2007-12-01
- Completion
- 2008-07-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Iloprost | Other / unclassified | 5 ug | Inhaled |
| Background | Bosentan | Other / unclassified | 62.5 mg | Oral |
| Background | Bosentan | Other / unclassified | 125 mg | Oral |
| Background | Sildenafil | Unknown | 60 mg | Oral |
| Background | Sildenafil | Unknown | 300 mg | Oral |