Pioglitazone in Impaired Glucose Tolerance

Summary

In patients with impaired glucose tolerance (IGT), the researchers want to study the relative effects of pioglitazone, simvastatin, or the combination of both on: * intima media thickness (IMT) as an easily assessed marker of atherosclerosis * heart rate variability (HRV) as a marker of autonomic neuropathy * flow-mediated vasodilatation (FMD) of the brachial artery as a marker of endothelial function * vascular and metabolic lab parameters

Timeline

Start

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Primary completion

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Completion

2009-05

Publications

• Ipsen EO, Madsen KS, Chi Y, Pedersen-Bjergaard U, Richter B, Metzendorf MI, Hemmingsen B. Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk for the development of type 2 diabetes mellitus. Cochrane Database Syst Rev. 2020 Nov 19;11(11):CD013516. doi: 10.1002/14651858.CD013516.pub2.

Drugs

Indications