TBI Dose De-escalation for Fanconi Anemia

Phase 2/3 Completed 83 enrolled Masonic Cancer Center, University of Minnesota

NaSingle-groupOpen-labelTreatment

Summary

This is a single arm, total body irradiation (TBI) trial. All patients will be prescribed TBI 300 cGy with the goal of evaluating secondary endpoints.

Timeline

Start: 2006-05-18
Primary completion: 2020-10-09
Completion: 2020-10-09

Publications

Background MacMillan ML, DeFor TE, Young JA, Dusenbery KE, Blazar BR, Slungaard A, Zierhut H, Weisdorf DJ, Wagner JE. Alternative donor hematopoietic cell transplantation for Fanconi anemia. Blood. 2015 Jun 11;125(24):3798-804. doi: 10.1182/blood-2015-02-626002. Epub 2015 Mar 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Cyclophosphamide	Other / unclassified	10 mg/kg	Intravenous
Background	Fludarabine	Small molecule	35 mg/m2	Intravenous
Background	Mycophenolate Mofetil	Small molecule	15 mg/kg	Oral
Background	Sirolimus	Small molecule	4 mg	Oral

TBI Dose De-escalation for Fanconi Anemia

Summary

Timeline

Publications

Drugs

Indications