drugset / Trial / NCT00384995
Bicarbonate v Saline to Prevent Contrast Nephropathy
Phase 4
Terminated
61 enrolled
Italian Society of Nephrology
European Commission · collabMemorial University of Newfoundland · collab
RandomizedParallel-groupOpen-labelPrevention
Summary
Slowing of kidney function occurs in a minority of people given dye during angiography. The purpose of this study is to compare two different types of fluid given into a vein to reduce the risk of kidney injury: salt in water or baking soda in water.
Timeline
- Start
- 2006-12
- Primary completion
- 2009-07
- Completion
- 2009-07
Publications
- Background Merten GJ, Burgess WP, Gray LV, Holleman JH, Roush TS, Kowalchuk GJ, Bersin RM, Van Moore A, Simonton CA 3rd, Rittase RA, Norton HJ, Kennedy TP. Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA. 2004 May 19;291(19):2328-34. doi: 10.1001/jama.291.19.2328.
- Ravani P, Tripepi G, Pecchini P, Mallamaci F, Malberti F, Zoccali C. Urotensin II is an inverse predictor of death and fatal cardiovascular events in chronic kidney disease. Kidney Int. 2008 Jan;73(1):95-101. doi: 10.1038/sj.ki.5002565. Epub 2007 Oct 17.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | sodium bicarbonate | Diagnostic / imaging agent | 166 meq | Intravenous |
| Comparator | sodium chloride | Unknown | 154 meq | Intravenous |