drugset / Trial / NCT00427648
Local Anesthetic Treatments for Overactive Bladder
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to determine whether alkalized lidocaine instilled into the bladder is effective in the treatment of overactive bladder (OAB).
Timeline
- Start
- 2006-03
- Primary completion
- 2010-05
- Completion
- 2010-05
Publications
- Background Wein AJ, Rovner ES. Definition and epidemiology of overactive bladder. Urology. 2002 Nov;60(5 Suppl 1):7-12; discussion 12. doi: 10.1016/s0090-4295(02)01784-3.
- Background HAINES JS, GRABSTALD H. Xylocaine; a new topical anesthetic in urology. J Urol. 1949 Dec;62(6):901. doi: 10.1016/S0022-5347(17)69020-7. No abstract available.
- Background Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology. 2005 Jan;65(1):45-8. doi: 10.1016/j.urology.2004.08.056.
- Background Coyne K, Revicki D, Hunt T, Corey R, Stewart W, Bentkover J, Kurth H, Abrams P. Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: the OAB-q. Qual Life Res. 2002 Sep;11(6):563-74. doi: 10.1023/a:1016370925601.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Lidocaine | Other / unclassified | 1 % | Other |
| Comparator | Lidocaine | Other / unclassified | 30 ml | Other |
| Comparator | sodium bicarbonate | Diagnostic / imaging agent | 0.9 % | Other |
| Comparator | sodium bicarbonate | Diagnostic / imaging agent | 10 ml | Other |