drugset / Trial / NCT00460239
Buprenorphine's Dose Response Curve
Phase 2
Completed
12 enrolled
Johns Hopkins University
National Institute on Drug Abuse (NIDA) · collab
RandomizedSingle-groupDouble-blindTreatment
Summary
This is a residential study that looks at the effects of buprenorphine in persons who abuse but are not dependent on opioids. Animal studies show that very high doses of buprenorphine produce less effects than mid-range doses. This suggests that buprenorphine can be a very safe medication. However, no studies in humans have tested higher doses in a similar way. The goal of this study is to show the effects of single doses of buprenorphine, across a range of doses, in persons who are not physically dependent on opioids (but do abuse opioids).
Timeline
- Start
- 2007-01
- Primary completion
- 2009-07
- Completion
- 2009-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine | Other / unclassified | 8 mg | Intramuscular |
| Subject | Buprenorphine | Other / unclassified | 16 mg | Intramuscular |
| Subject | Buprenorphine | Other / unclassified | 32 mg | Intramuscular |
| Subject | Buprenorphine | Other / unclassified | 48 mg | Intramuscular |
| Subject | Buprenorphine | Other / unclassified | 60 mg | Intramuscular |
| Subject | Morphine | Other / unclassified | 15 mg | Intramuscular |
| Subject | Morphine | Other / unclassified | 30 mg | Intramuscular |