Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both

Summary

The purpose of this study is to compare the percent change in LDL cholesterol induced by ezetimibe or simvastatin monotherapy and by co-administration of both agents in Black, White and Hispanic men. Ezetimibe is a drug that blocks sterol absorption and simvastatin blocks hepatic cholesterol biosynthesis. The hypothesis to be tested is that Blacks are likely to be more responsive to LDL lowering by ezetimibe than statins because Blacks have a low production of cholesterol.

Timeline

Start

2005-02

Primary completion

—

Completion

2007-04

Drugs

Indications