drugset / Trial / NCT00462787
Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Leukemia
Phase 1
Completed
23 enrolled
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI) · collab
NaSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy, such as clofarabine, topotecan, vinorelbine, thiotepa, and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. PURPOSE: This phase I trial is studying the side effects and best dose of clofarabine when given together with topotecan, vinorelbine, thiotepa, and dexamethasone in treating young patients with relapsed or refractory acute leukemia.
Timeline
- Start
- 2007-04
- Primary completion
- 2013-11
- Completion
- 2013-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clofarabine | Other / unclassified | — | Intravenous |
| Background | Dexamethasone | Small molecule | — | Oral |
| Background | Thiotepa | Other / unclassified | — | Intravenous |
| Background | Topotecan | Small molecule | — | Intravenous |
| Background | Vinorelbine | Small molecule | — | — |
| Background | filgrastim | Protein / enzyme biologic | — | Subcutaneous |