drugset / Trial / NCT00479466
Dose-Range Finding Study for MK0893 (0893-008)
RandomizedParallel-groupDouble-blindTreatment
Summary
A study to compare MK0893 to metformin or placebo for patients with Type 2 diabetes (Diabetes Mellitus).
Timeline
- Start
- 2007-07
- Primary completion
- 2008-05
- Completion
- 2008-05
Outcome
Met primary endpoint
Stopped: “Sufficient data regarding the dose-response to MK-0893 had been obtained from the first cohort of the study to assess the safety and efficacy”
registry analysis (superiority or other test); Placebo vs MK0893 20 mg; p <0.001; Mean Difference (Final Values) -30.6 (95% CI -44.0 to -17.3); ANCOVA NCT00479466 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | MK-0893 | Small molecule | 20 mg | Oral |
| Subject | MK-0893 | Small molecule | 40 mg | Oral |
| Subject | MK-0893 | Small molecule | 60 mg | Oral |
| Subject | MK-0893 | Small molecule | 80 mg | Oral |
| Comparator | Metformin | Small molecule | 1000 mg | — |