drugset

drugset / Trial / NCT00522756

Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy

NCT00522756 ↗

Phase 3 Unknown 200 enrolled McGill University Health Centre/Research Institute of the McGill University Health Centre

RandomizedParallel-groupTriple-blindPrevention

Summary

The purpose of this study is to determine whether sodium bicarbonate is effective in reducing kidney injury that may occur during cardiac surgery.

Timeline

Start: 2006-05
Primary completion: 2012-12
Completion: 2013-03

Publications

Background Merten GJ, Burgess WP, Gray LV, Holleman JH, Roush TS, Kowalchuk GJ, Bersin RM, Van Moore A, Simonton CA 3rd, Rittase RA, Norton HJ, Kennedy TP. Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA. 2004 May 19;291(19):2328-34. doi: 10.1001/jama.291.19.2328.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium bicarbonate	Diagnostic / imaging agent	7.5 %	Intravenous
Comparator	sodium chloride	Unknown	0.9 %	Intravenous

Indications