drugset / Trial / NCT00555984

Intravenous Anesthesia Versus Anesthesia With Volatile Agents in Elective Craniotomy for Tumors

NCT00555984 ↗

RandomizedParallel-groupTriple-blindPrevention

Summary

If the anesthetic regimen can influence the serum level of inflammatory cytokines and if the levels of cytokines are related to the incidence of post operative complications, these complications may be a function of the anesthetic method. In an effort to find the best anesthetic regimen for patients undergoing craniotomy for intracranial tumors, the researchers will compare the effect of volatile anesthetic with that of total intravenous anesthesia (TIVA) on cytokine levels. The researchers will also compare the composite incidence of some common major post-operative complications after craniotomy for intracranial malignancy.

Timeline

Start
2007-09
Primary completion
2010-03
Completion
2010-03

Outcome

Outcome not reported

Stopped: “PI decision to terminate. No usable data collected”

Drugs

EvaluationDrugModalityDoseRoute
Comparator Propofol Small molecule — Intravenous
Comparator Remifentanil Small molecule — Intravenous
Comparator Sevoflurane Other / unclassified — Inhaled

Indications