drugset / Trial / NCT00560690
The Effect of Adding Metformin to the Treatment of Hepatitis C
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Insulin resistance is known to adversely effect viral response to treatment in hepatitis C patients We are aiming to study the effect of an insulin sensitizer, metformin, in viral response of hepatitis C to treatment with pegylated interferon and ribavirin in a double blind randomized controlled trial
Timeline
- Start
- 2007-12
- Primary completion
- 2010-09
- Completion
- 2010-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metformin | Small molecule | 500 mg | Oral |
| Background | Peginterferon alfa-2a | Protein / enzyme biologic | 1.5 ug/kg | Subcutaneous |
| Background | Peginterferon alfa-2a | Protein / enzyme biologic | 180 ug | Subcutaneous |
| Background | Ribavirin | Small molecule | 800 mg | Oral |
| Background | Ribavirin | Small molecule | 1200 mg | Oral |