Antipyretics for Preventing Recurrences of Febrile Seizures

Phase 4 Completed 231 enrolled University of Oulu

RandomizedParallel-groupQuadruple-blindPrevention

Summary

We wanted to find out if the early use of antipyretics is capable in preventing recurrences of febrile seizures. When a child has had his/her first febrile seizure, the parents were instructed to give him/her antipyretic medication every time when the child had a new episode of fever during two years.

Timeline

Start: 1997-09
Primary completion: —
Completion: 2005-08

Publications

Strengell T, Uhari M, Tarkka R, Uusimaa J, Alen R, Lautala P, Rantala H. Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial. Arch Pediatr Adolesc Med. 2009 Sep;163(9):799-804. doi: 10.1001/archpediatrics.2009.137.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Acetaminophen	Small molecule	15 mg/kg	Oral
Comparator	Diclofenac	Other / unclassified	1.5 mg/kg	Rectal
Comparator	Ibuprofen	Small molecule	10 mg/kg	Oral

Indications

No indication recorded.