drugset / Trial / NCT00585559
Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm
Phase 3
Terminated
44 enrolled
Vanderbilt University Medical Center
National Institute of General Medical Sciences (NIGMS) · collabNational Institutes of Health (NIH) · collab
RandomizedFactorialQuadruple-blindTreatment
Summary
The objective of this study is to determine whether acetaminophen (APAP), N-acetylcysteine (NAC), and APAP in combination with NAC will inhibit lipid peroxidation in aneurysmal subarachnoid hemorrhage (aSAH), utilizing F2-IsoPs as biomarkers for lipid peroxidation.
Timeline
- Start
- 2007-04
- Primary completion
- 2023-10-26
- Completion
- 2023-10-26
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 1 g | — |
| Comparator | Acetaminophen | Small molecule | 1.5 g | — |
| Comparator | N-acetylcysteine | Small molecule | 0.5 g | Intravenous |