Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy

Phase 4 Completed 500 enrolled Ospedale Misericordia e Dolce

RandomizedParallel-groupDouble-blindPrevention

Summary

Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans. We compared the efficacy of sodium bicarbonate versus isotonic saline to prevent CIN in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.

Timeline

Start: 2005-01
Primary completion: —
Completion: 2006-03

Publications

Maioli M, Toso A, Leoncini M, Gallopin M, Tedeschi D, Micheletti C, Bellandi F. Sodium bicarbonate versus saline for the prevention of contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. J Am Coll Cardiol. 2008 Aug 19;52(8):599-604. doi: 10.1016/j.jacc.2008.05.026.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium bicarbonate	Diagnostic / imaging agent	154 meq	—
Comparator	sodium chloride	Unknown	0.9 %	—

Indications

No indication recorded.