Remifentanil and Propofol Versus Fentanyl and Midazolam for Sedation During Therapeutic Hypothermia. A Randomised, Controlled Trial

Phase 4 Completed 60 enrolled Norwegian University of Science and Technology St. Olavs Hospital · collab

RandomizedParallel-groupOpen-labelSupportive care

Summary

The aim of this study is to increase knowledge about drug properties and effects during therapeutic hypothermia. The primary end point of this study is the time from termination of sedation to extubation in patients treated with therapeutic hypothermia, after treatment with the combination remifentanil and propofol versus that of fentanyl and midazolam.

Timeline

Start: 2008-04
Primary completion: 2009-05
Completion: 2010-06

Publications

Results Bjelland TW, Dale O, Kaisen K, Haugen BO, Lydersen S, Strand K, Klepstad P. Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trial. Intensive Care Med. 2012 Jun;38(6):959-67. doi: 10.1007/s00134-012-2540-1. Epub 2012 Apr 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Fentanyl	Other / unclassified	—	Intravenous
Comparator	Midazolam	Small molecule	—	Intravenous
Comparator	Propofol	Small molecule	—	Intravenous
Comparator	Remifentanil	Small molecule	—	Intravenous

Indications

No indication recorded.