Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia

Completed 32 enrolled University of Oklahoma

RandomizedParallel-groupOpen-labelHealth-services research

Summary

The study hypothesizes that adding 60% nitrous oxide to a steady state sevoflurance or propofol anesthetic will lead to a decrease in both BIS and Entropy indices during a constant level of surgical stimulus

Timeline

Start: 2008-03
Primary completion: 2010-10
Completion: 2010-10

Publications

Background Anderson RE, Jakobsson JG. Entropy of EEG during anaesthetic induction: a comparative study with propofol or nitrous oxide as sole agent. Br J Anaesth. 2004 Feb;92(2):167-70. doi: 10.1093/bja/aeh036.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Nitrous Oxide	Other / unclassified	60 %	—
Comparator	Propofol	Small molecule	—	—
Comparator	Sevoflurane	Other / unclassified	—	—

Indications

No indication recorded.