Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects

Summary

The aim of the current study is to evaluate whether treatment with high doses of simvastatin can reduce coagulation activation in patients with acute coronary syndromes and if ezetimibe in conjunction with simvastatin may affect blood clotting in a similar manner. The investigators hypotheses are as follows: 1. Intensive lipid lowering treatment with simvastatin (40 mg/day) and simvastatin (40 mg/day) combined with ezetimibe (10 mg/day) initiated after acute coronary syndrome leads to attenuation of blood coagulation including reduced thrombin generation, thrombin-mediated coagulant reactions, and improved structure of plasma clots. 2. Anticoagulant effects of simvastatin are weaker than those observed during administration of simvastatin and ezetimibe.

Timeline

Start

2008-06

Primary completion

2009-06

Completion

2009-12

Publications

• Undas A, Machnik A, Potaczek DP, Wypasek E, Zmudka K, Tracz W. Ezetimibe combined with simvastatin compared with simvastatin alone results in a greater suppression of oxidative stress and enhanced fibrinolysis in patients after acute coronary events. J Cardiovasc Pharmacol. 2011 Aug;58(2):167-72. doi: 10.1097/FJC.0b013e31821e8cb2.

Drugs

Indications