drugset / Trial / NCT00726960
Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers
Phase 1
Unknown
60 enrolled
Karolinska University Hospital
County of Stockholm · collabMinistry of Health and Social Affairs, Sweden · collab
RandomizedSingle-groupDouble-blindTreatment
Summary
The objective of this study is to determine whether aprepitant blocks the opiate reward system in non-dependent opiate abusers, indicating its potential as a safe, non-addictive first line therapy for early heroin abuse.
Timeline
- Start
- 2008-01
- Primary completion
- 2009-12
- Completion
- 2010-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aprepitant | Other / unclassified | 125 mg | Oral |
| Comparator | Buprenorphine | Other / unclassified | 0.4 mg | Other |
| Comparator | Buprenorphine | Other / unclassified | 8 mg | Other |