Depodur vs Fentanyl Infusion for Post-C/S Analgesia

Withdrawn Goodman, Evan, M.D.

RandomizedParallel-groupSingle-blindTreatment

Summary

Epidurally administered Depodur provides equal or superior analgesia as an epidural infusion of fentanyl for the first 48 hours after a cesarean section.

Timeline

Start: 2008-10
Primary completion: 2009-06
Completion: 2009-06

Outcome

Outcome not reported

Stopped: “Uncertain safety of one of the study medications.”

Publications

Background Carvalho B, Riley E, Cohen SE, Gambling D, Palmer C, Huffnagle HJ, Polley L, Muir H, Segal S, Lihou C, Manvelian G; DepoDur Study Group. Single-dose, sustained-release epidural morphine in the management of postoperative pain after elective cesarean delivery: results of a multicenter randomized controlled study. Anesth Analg. 2005 Apr;100(4):1150-1158. doi: 10.1213/01.ANE.0000149544.58230.FF.
Background Carvalho B, Roland LM, Chu LF, Campitelli VA 3rd, Riley ET. Single-dose, extended-release epidural morphine (DepoDur) compared to conventional epidural morphine for post-cesarean pain. Anesth Analg. 2007 Jul;105(1):176-83. doi: 10.1213/01.ane.0000265533.13477.26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Fentanyl	Other / unclassified	—	Other
Comparator	Morphine	Other / unclassified	10 mg	Other

Indications

No indication recorded.