drugset / Trial / NCT00795808
PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene
Phase 4
Completed
171 enrolled
University of Auckland, New Zealand
Auckland Medical Research Foundation · collabMercia Barnes Trust of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
1. Metformin increases the pregnancy rate when added to the standard treatment of anovulatory polycystic ovary syndrome (PCOS). 2. Metformin in combination with clomiphene, is more effective than clomiphene alone or metformin alone improves fertility outcomes in women with PCOS of reasonably healthy body weight (BMI \</= 32). 3. Metformin improves fertility outcomes in women with BMI \> 32 with PCOS.
Timeline
- Start
- 2003-08
- Primary completion
- 2008-10
- Completion
- 2008-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clomiphene | Other / unclassified | — | — |
| Subject | Metformin | Small molecule | 500 mg | — |