drugset / Trial / NCT00812825
A Phase 1 Multiple-Dose Escalation and Single Dose (Tablet) Study of PF-04171327 in Healthy Volunteers
RandomizedParallel-groupDouble-blindBasic science
Summary
The purpose of this study is to determine the safety, tolerability, pharmacokinetics and pharmacodynamics (how the drug effects certain target sites of activity in the body) of escalating doses of oral PF-04171327 in healthy volunteers for 14 days (Part 1). Part 2 will evaluate the pharmacokinetics of a single 10 mg dose of the PF-04171327 tablet in healthy volunteers.
Timeline
- Start
- 2009-01
- Primary completion
- 2009-07
- Completion
- 2009-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Prednisolone | Other / unclassified | 5 mg | Oral |
| Comparator | Prednisolone | Other / unclassified | 10 mg | Oral |
| Comparator | Prednisolone | Other / unclassified | 20 mg | Oral |
| Subject | fosdagrocorat | Small molecule | 1 mg | Oral |
| Subject | fosdagrocorat | Small molecule | 3 mg | Oral |
| Subject | fosdagrocorat | Small molecule | 10 mg | Oral |
| Subject | fosdagrocorat | Small molecule | 30 mg | Oral |
Indications
No indication recorded.