drugset / Trial / NCT00878306
Disulfiram Interactions With HIV Medications: Clinical Implications
Phase 1
Completed
40 enrolled
University of California, San Francisco
National Institute on Drug Abuse (NIDA) · collab
RandomizedSingle-groupOpen-label
Summary
The purpose of this study is to determine whether disulfiram might be a safe and effective treatment for cocaine and/or alcohol dependence in patients with HIV disease. This research is designed to characterize the presence or absence of significant drug interactions between disulfiram and HIV medications using standard clinical pharmacology techniques as well as monitor any side effects that might occur when these medications are administered together.
Timeline
- Start
- 2008-11
- Primary completion
- 2013-04
- Completion
- 2013-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atazanavir | Other / unclassified | 400 mg | — |
| Comparator | Disulfiram | Small molecule | 250 mg | — |
| Subject | Efavirenz | Other / unclassified | 600 mg | — |
| Subject | Ritonavir | Other / unclassified | 200 mg | — |