A Study to Investigate the Efficacy and Safety of Different Doses of Losartan Potassium (MK0954-011)

Phase 3 Completed 576 enrolled Merck Sharp & Dohme LLC

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study was to compare the antihypertensive efficacy of different doses of losartan compared to placebo and enalapril, in patients with supine diastolic blood pressure of 100-115 mmHg.

Timeline

Start: 1990-12
Primary completion: 1991-08
Completion: 1992-01

Publications

Background Gradman AH, Arcuri KE, Goldberg AI, Ikeda LS, Nelson EB, Snavely DB, Sweet CS. A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension. Hypertension. 1995 Jun;25(6):1345-50. doi: 10.1161/01.hyp.25.6.1345.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Enalapril	Other / unclassified	20 mg	Oral
Subject	Losartan	Other / unclassified	10 mg	Oral
Subject	Losartan	Other / unclassified	25 mg	Oral
Subject	Losartan	Other / unclassified	50 mg	Oral
Subject	Losartan	Other / unclassified	100 mg	Oral
Subject	Losartan	Other / unclassified	150 mg	Oral

A Study to Investigate the Efficacy and Safety of Different Doses of Losartan Potassium (MK0954-011)

Summary

Timeline

Publications

Drugs

Indications