drugset / Trial / NCT00886002
Comparison of Two Dosage Strengths of Transdermal Fentanyl Versus Transdermal Buprenorphine and Placebo in Acute Pain Models in Healthy Volunteers.
RandomizedCrossoverDouble-blindTreatment
Summary
The primary objective of this pilot trial is to identify pain model(s) which allow(s) to compare and differentiate the analgesic effects between transdermal fentanyl 25µg/h, transdermal fentanyl 12µg/h and placebo in a dose dependent way. The second objective is to compare the effects of transdermal buprenorphine 35µg/h in these models with the effect of the two transdermal fentanyl dosages. Therefore four different treatments are given; all treatments will be by means of a patch that is attached to the back for 72 hours.
Timeline
- Start
- 2004-11
- Primary completion
- —
- Completion
- 2005-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine | Other / unclassified | 35 ug | Other |
| Subject | Fentanyl | Other / unclassified | 12 ug | Other |
| Subject | Fentanyl | Other / unclassified | 25 ug | Other |
| Background | Naloxone | Small molecule | — | — |
Indications
No indication recorded.