drugset / Trial / NCT00920088
Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs
Non-randomizedParallel-groupOpen-labelBasic science
Summary
The purpose of this study is to evaluate the effect of GSK2448761 on CYP450 metabolic probes and to evaluate the 2-way interaction between GSK2448761 and two ritonavir-boosted protease inhibitors that are commonly used in HIV-infected subjects.
Timeline
- Start
- 2009-06
- Primary completion
- 2009-11
- Completion
- 2009-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Darunavir | Small molecule | 600 mg | — |
| Subject | Dextromethorphan | Unknown | 30 mg | — |
| Subject | FOSDEVIRINE | Small molecule | — | — |
| Subject | Flurbiprofen | Small molecule | 50 mg | — |
| Subject | Lopinavir | Other / unclassified | 400 mg | — |
| Subject | Midazolam | Small molecule | 3 mg | — |
| Subject | Ritonavir | Other / unclassified | 100 mg | — |