drugset / Trial / NCT00995670
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Non-randomizedSingle-groupOpen-labelBasic science
Summary
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and then a re-establishment of flow. The blood vessel lining plays a key role in this injury. This research will examine, in human volunteers, several important modifiers of APC in human blood vessels: high blood sugar, vitamin C, and statin drugs. Thus, the proposed studies will advance the investigators' understanding of mechanisms of this injury in humans and explore important modifiers of APC protection from injury.
Timeline
- Start
- 2010-03
- Primary completion
- 2013-09
- Completion
- 2013-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 5% dextrose | Unknown | 5 % | — |
| Subject | Sevoflurane | Other / unclassified | 1 unknown | — |
| Subject | Simvastatin | Small molecule | 40 mg | Oral |
| Subject | Vitamin C | Other / unclassified | 1 g | Intravenous |