drugset / Trial / NCT01026129

Efficacy of Remifentanil Compared to Lidocaine on the Incidence of Coughing During Emergence of Anesthesia

NCT01026129

RandomizedParallel-groupDouble-blindPrevention

Summary

This study is designed to compare the effects of a bolus dose of remifentanil to a bolus dose of lidocaine given prior to the emergence of anesthesia: * on the incidence of perioperative coughing * on the time needed for the emergence of a desflurane-based anesthesia * on the incidence of sore throat after extubation. Our hypothesis is that the use of a remifentanil bolus dose given prior to emergence of a desflurane-based anesthesia will reduce the incidence of perioperative coughing from 70% to 35% compared to lidocaine.

Timeline

Start
2010-04
Primary completion
2010-06
Completion
2010-07

Drugs

EvaluationDrugModalityDoseRoute
Comparator Lidocaine Other / unclassified 1 mg/kg Intravenous
Subject Remifentanil Small molecule 0.25 ug/kg Intravenous
Subject Remifentanil Small molecule 0.5 ug/kg Intravenous

Indications

No indication recorded.