Gabapentin in the Prevention of Nausea and Vomiting Induced by Chemotherapy

Summary

Gabapentin is an antiepileptic drug. Its antiemetic effect is demonstrated after laparoscopic surgery, but it is not yet known whether gabapentin is effective in preventing chemotherapy induced emesis. The purpose of this study is to determine whether the addition of gabapentin to dexamethasone plus ondansetron increase the control of chemotherapy-induced nausea and vomiting.

Timeline

Start

2009-01

Primary completion

2010-07

Completion

2010-07

Outcome

Mixed primary results

paper The proportion of patients achieving complete response improved from 40% to 62.5%, (p = 0.04) when comparing the control group and the gabapentin group, respectively. PMID 21465325 ↗

registry analysis (superiority or other test); Control Group vs Gabapentin; p = 0.06; Chi-squared NCT01052844 ↗

Publications

• Cruz FM, de Iracema Gomes Cubero D, Taranto P, Lerner T, Lera AT, da Costa Miranda M, da Cunha Vieira M, de Souza Fede AB, Schindler F, Carrasco MM, de Afonseca SO, Pinczowski H, del Giglio A. Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study. Support Care Cancer. 2012 Mar;20(3):601-6. doi: 10.1007/s00520-011-1138-4. Epub 2011 Apr 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gabapentin	Unknown	300 mg	Oral
Comparator	Dexamethasone	Small molecule	4 mg	Intravenous
Comparator	Ondansetron	Other / unclassified	8 mg	—
Comparator	Ranitide	Unknown	50 mg	—

Indications