drugset / Trial / NCT01059929
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
Phase 4
Terminated
41 enrolled
University of Chicago
Hospira, now a wholly owned subsidiary of Pfizer · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (\> 24 hours) in critically ill patients who require mechanical ventilation.
Timeline
- Start
- 2009-09
- Primary completion
- 2015-09
- Completion
- 2015-09
Outcome
Outcome not reported
Stopped: “drug and placebo unavailable”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.2 ug/kg | Intravenous |
| Comparator | Dexmedetomidine | Other / unclassified | 1.5 ug/kg | Intravenous |
| Comparator | Propofol | Small molecule | 5 ug/kg | Intravenous |
| Comparator | Propofol | Small molecule | 50 ug/kg | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 25 ug | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 200 ug | Intravenous |
| Comparator | Midazolam | Small molecule | 0.01 mg/kg | Intravenous |
| Comparator | Midazolam | Small molecule | 0.1 mg/kg | Intravenous |