Cutaneous Iontophoresis of Iloprost and Treprostinil in Healthy Volunteers

Phase 1/2 Completed 20 enrolled University Hospital, Grenoble

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to test whether prostacyclin analogues' cathodal iontophoresis induce a cutaneous vasodilation in healthy volunteers's forearm, without local side effects.

Timeline

Start: 2010-01
Primary completion: 2011-01
Completion: 2011-01

Publications

Blaise S, Roustit M, Hellmann M, Millet C, Cracowski JL. Cathodal iontophoresis of treprostinil induces a sustained increase in cutaneous blood flux in healthy volunteers. J Clin Pharmacol. 2013 Jan;53(1):58-66. doi: 10.1177/0091270011434352. Epub 2013 Jan 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Iloprost	Other / unclassified	2 unknown	Other
Subject	Iloprost	Other / unclassified	20 unknown	Other
Subject	Iloprost	Other / unclassified	200 unknown	Other
Subject	Treprostinil	Other / unclassified	2.5 unknown	Other
Subject	Treprostinil	Other / unclassified	25 unknown	Other
Subject	Treprostinil	Other / unclassified	250 unknown	Other

Indications

No indication recorded.